Transplantation Research Lab - Homepage
Transplantation Research Lab
UCSF Transplant Surgery Program
Welcome to the Transplantation Research Lab
The Transplantation Research Lab is dedicated to the discovery of new and more effective methods for preventing and managing the rejection of transplanted organs. Current projects include:
- Understanding how regulatory T cells (specialized immune cells) prevent autoimmune diabetes and transplant rejection
- Engineering dendritic cells (DCs) to inhibit donor-specific T cells and targeting DCs to lymphoid organs
- Investigational use of the immunosuppressive drug called Belatacept to control graft rejection
- Studying the effects of gaseous carbon monoxide to increase anti-inflammatory response
- Establishing successful protocols for withdrawal from immunosuppressive regimens
Support the Lab
A gift to the Transplantation Research Lab will help with the discovery of new treatments and cures for liver disease.
Featured News
Aquaporin 9 induction in human iPSC-derived hepatocytes facilitates modeling of ornithine transcarbamylase deficiency.
2021 | PubMed
Featured Publications
- Adipocyte inflammation is the primary driver of hepatic insulin resistance in a human iPSC-based microphysiological system.
2024 | PubMed - Human Hepatocytes Can Give Rise to Intrahepatic Cholangiocarcinomas.
2024 | PubMed - Modeling and therapeutic targeting of inflammation-induced hepatic insulin resistance using human iPSC-derived hepatocytes and macrophages.
2023 | PubMed - Human iPSC-Derived Proinflammatory Macrophages cause Insulin Resistance in an Isogenic White Adipose Tissue Microphysiological System.
2023 | PubMed - Reply.
2022 | PubMed